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Experts warn Ozempic users could develop protein and vitamin D shortages

Digilifetrends Updated 2026-10-26 1 min read

(NewsNation) — Patients taking Ozempic and other GLP-1 medications may be vulnerable to nutritional deficiencies, according to recent research.

These drugs can reduce appetite and slow digestion, which often leads people to eat less. That lower intake can raise the risk of missing important nutrients and has prompted concern among doctors and nutrition researchers.

Studies have highlighted several nutrients of concern, including protein, fiber, vitamin B12, vitamin D, electrolytes, and other nutrients needed to support muscle mass and connective tissue.

Could Ozempic users become protein deficient?

One obesity study found that 43% of GLP-1 users consumed too little protein during the trial period.

Researchers at the University of Cambridge have also voiced concern that patients prescribed newer weight-loss drugs may not be getting enough nutritional guidance to help them lose weight safely and healthfully.

A review of research found that GLP-1 users consumed 16% to 39% fewer calories than people taking a placebo.

With fewer calories overall, some users may struggle to get enough protein and other micronutrients from their diets.

Doctors advise speaking with a registered dietitian nutritionist for help improving diet quality.

The Academy of Nutrition and Dietetics offers a directory of nutrition professionals that people can search by insurance, location and specialty.

Vitamin D deficiencies

Research suggests vitamin D may be the deficiency most likely to affect GLP-1 users. A large study found that 13.6% of participants were affected.

Another study in the journal Childhood Obesity found that vitamin D deficiency was the most common deficiency among children taking GLP-1 medications, affecting 12.4% of participants after one year of treatment.

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