Chrissy Metz opens up about unexpected GLP-1 effects after major weight loss

Chrissy Metz has shared more details about how her GLP-1-assisted weight loss journey has been going.

Best known for her role in the hit drama This Is Us, Metz said earlier that she had decided to use medication to help with weight loss, even though she had long been skeptical about it.

A friend helped change her perspective. Speaking to E! News, Metz said: "I had a friend who was very thorough in his explanation, and he basically did a thesis on GLP-1s, alongside some information about the health history and of my family and my father."

That led her to decide the drugs were something she should "look into," and she has since lost 100lbs.

Metz showed off her weight loss at the recent Nocturne premiere, where she wore a green velvet dress. The Apple TV drama stars her alongside Stephen Graham and Liev Schreiber.

At the event, she spoke with Entertainment Tonight about how life has changed since using GLP-1s.

One benefit, she said, has been during her Broadway work, which was physically demanding.

"Being able to run around a stage eight times a week was really amazing," Metz said. "The inflammation was really minimalized."

She added: "I’m perimenopausal, I got knee issues, there’s things going on. Just the mental capacity to have other things to think about than obsessing about the food noise, that’s been super, super helpful. It’s been great."

Metz has also faced criticism from some people over her decision to use GLP-1s, and the 46-year-old has pushed back against it.

"I mean, people are going to criticize you no matter what you do, no matter what you say, how you dress, what you look like — thin, overweight, mid-size, whatever," she told Us Weekly. "Somebody’s always going to have something to say, and that’s OK. They’re entitled to their opinions."

She continued: "I don’t listen to them. I never have, but I think that not one thing is for everybody. We don’t all drive the same car, we don’t all wear the same makeup, we don’t all use the same beauty products because everything is different for everybody.

"And until you know, you don’t know. That’s how I felt. I was like, 'I’m never going to take one of these things.' And I realized, 'Oh, it could be super beneficial,' and it has been."